Across TCGA patient cohorts, CNOT7 protein abundance is significantly associated with the RNA expression of many other genes, with 4,646 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible CNOT7-associated genes across cancer lineages are XPO7, AGPAT5, and PBK. Each is linked with CNOT7 in more than 6 cancer types. Because this analysis shows association rather than direction, both CNOT7-to-partner and partner-to-CNOT7 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNOT7→partner) and Y-score (partner→CNOT7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	XPO7 →	+0.623	+0.288	<.001	<.001	3	7
BRCA	AGPAT5 →	+0.688	+0.189	<.001	<.001	3	6
LUAD	PBK →	+1.204	+0.203	<.001	<.001	3	6
BRCA	PPP2R2A →	+0.616	+0.194	<.001	.001	3	6
UCEC	INTS9 →	+0.429	+0.108	.002	.001	3	5
HNSC	ESCO2 →	+0.621	+0.117	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,646 associations by consensus.

Exploration

CNOT7 survival (RNA) · tumor vs normal (RNA) · all CNOT7 data types