Across TCGA patient cohorts, CNOT7 mutation is significantly associated with the RNA expression of many other genes, with 3,460 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNOT7-associated genes across cancer lineages are TXN2, ADNP2, and USP14. Each is linked with CNOT7 in more than 1 cancer types. Because this analysis shows association rather than direction, both CNOT7-to-partner and partner-to-CNOT7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNOT7→partner) and Y-score (partner→CNOT7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TXN2 →	+0.349	+3.266	.003	<.001	3	2
UCEC	ADNP2 →	+0.833	+3.947	<.001	<.001	3	2
UCEC	USP14 →	+0.589	+3.721	<.001	<.001	3	2
UCEC	VPS18 →	+0.430	+3.475	.008	.002	3	2
UCEC	DCTN6 →	+0.526	+3.815	.001	<.001	3	2
UCEC	GSR →	+0.674	+3.343	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,460 associations by consensus.

Exploration

CNOT7 survival (RNA) · tumor vs normal (RNA) · all CNOT7 data types