CNOT6LP1

Across TCGA pan-cancer cohorts, CNOT6LP1 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of CNOT6LP1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CNOT6LP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CNOT6LP1 is over-expressed in tumor, although a few such as BRCA and PRAD show the opposite, repressed pattern.

HNSC, LUSC, and BLCA are the cancer types where CNOT6LP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CNOT6LP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.847	.005	8	view →
LUSC	Male	All	+0.631	<.001	4	view →
BLCA	Female	III,IV	+0.514	.025	4	view →
BRCA	Female	All	−0.115	.007	4	view →
CHOL	All	All	+0.281	.004	2	view →
PRAD	All	All	−0.197	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

CNOT6LP1–HNSC

Open the HNSC breakdown →