CNOT6L

Across TCGA patient cohorts, CNOT6L protein abundance is significantly associated with the RNA expression of many other genes, with 3,443 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible CNOT6L-associated genes across cancer lineages are MXRA5, LARP1B, and ARMH4. Each is linked with CNOT6L in more than 2 cancer types. Because this analysis shows association rather than direction, both CNOT6L-to-partner and partner-to-CNOT6L results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CNOT6L versus MXRA5 in BRCA, with a Pearson correlation of -0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNOT6L→partner) and Y-score (partner→CNOT6L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MXRA5 →	-1.094	-0.182	<.001	<.001	3	3
HNSC	LARP1B →	+0.461	+0.149	.001	.004	3	3
PDAC	ARMH4 →	-0.469	-0.224	.005	.004	3	3
LSCC	NANOS1 →	-0.378	-0.176	.002	.001	3	2
UCEC	CDH6 →	-1.454	-0.220	.005	.007	3	2
UCEC	HNF4G →	+1.027	+0.261	.007	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,443 associations by consensus.

CNOT6L vs MXRA5 — BRCA

Explore this scatter interactively →