CNOT6L

Across TCGA cell cohorts, CNOT6L mutation is significantly associated with the RNA expression of many other genes, with 55 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible CNOT6L-associated genes across cancer lineages are PRAMEF9, DPRX, and PFN3. Each is linked with CNOT6L in more than 2 cancer types. Because this analysis shows association rather than direction, both CNOT6L-to-partner and partner-to-CNOT6L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF9 grouped by CNOT6L-low versus CNOT6L-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNOT6L→partner) and Y-score (partner→CNOT6L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	PRAMEF9 →	+0.263	+5.357	<.001	.003	3	3
CNS	DPRX →	+0.068	+5.321	<.001	.005	3	2
LARGE_INTESTINE	PFN3 →	+0.166	+4.467	<.001	.004	3	2
UPPER_AERODIGESTIVE_TRACT	KCNK18 →	+0.059	+4.736	<.001	.009	3	2
UPPER_AERODIGESTIVE_TRACT	DGKK →	+0.006	+5.357	<.001	.003	3	2
URINARY_TRACT	LILRA1 →	+0.013	+5.087	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

PRAMEF9 by CNOT6L expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →