CNOT6

Across TCGA patient cohorts, CNOT6 protein abundance is significantly associated with the RNA expression of many other genes, with 4,945 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible CNOT6-associated genes across cancer lineages are KLF15, PDE4DIPP2, and PDZD11. Each is linked with CNOT6 in more than 2 cancer types. Because this analysis shows association rather than direction, both CNOT6-to-partner and partner-to-CNOT6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CNOT6 versus KLF15 in GBM, with a Pearson correlation of -0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNOT6→partner) and Y-score (partner→CNOT6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	KLF15 →	-1.350	-0.482	<.001	<.001	3	3
HNSC	PDE4DIPP2 →	-1.053	-0.455	.002	.002	3	3
HNSC	PDZD11 →	+0.540	+0.566	.002	<.001	3	2
LUAD	CANX →	+0.442	+0.266	.004	.008	3	2
LUAD	F12 →	+0.831	+0.291	<.001	.001	3	2
PDAC	MS4A1 →	-2.118	-0.752	.003	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,945 associations by consensus.

CNOT6 vs KLF15 — GBM

Explore this scatter interactively →