CNOT6

Across TCGA patient cohorts, CNOT6 mutation is significantly associated with the RNA expression of many other genes, with 3,088 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNOT6-associated genes across cancer lineages are RNU6-13P, LINC02509, and RNA5SP47. Each is linked with CNOT6 in more than 2 cancer types. Because this analysis shows association rather than direction, both CNOT6-to-partner and partner-to-CNOT6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-13P grouped by CNOT6-low versus CNOT6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNOT6→partner) and Y-score (partner→CNOT6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-13P →	+0.176	+1.732	.008	.008	3	3
LUAD	LINC02509 →	+0.298	+6.912	<.001	<.001	3	2
SKCM	RNA5SP47 →	+0.240	+3.010	<.001	.003	3	2
SKCM	CINP →	+0.433	+3.341	.004	.005	3	2
SKCM	ACOT2 →	+0.674	+3.341	.002	.005	3	2
SKCM	PSME3 →	+0.460	+3.328	.008	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,088 associations by consensus.

RNU6-13P by CNOT6 expression — UCEC

Explore this box plot interactively →