CNOT6

Across TCGA cell cohorts, CNOT6 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,594 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CNOT6-associated GO terms across cancer lineages are Heterochromatin organization, Heterochromatin formation, and Negative regulation of gene expression, epigenetic. Each is linked with CNOT6 in more than 18 cancer types. Because this analysis shows association rather than direction, both CNOT6-to-partner and partner-to-CNOT6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heterochromatin organization grouped by CNOT6-low versus CNOT6-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CNOT6→partner) and Y-score (partner→CNOT6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Heterochromatin organization →	+0.067	+0.537	<.001	<.001	3	19
STOMACH	Heterochromatin formation →	+0.071	+0.537	<.001	<.001	3	18
LIVER	Negative regulation of gene expression, epigenetic →	+0.073	+0.934	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Positive regulation of organelle assembly →	+0.065	+1.188	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Regulation of DNA-templated transcription elongation →	+0.068	+0.752	.001	.006	3	17
BONE	Epigenetic regulation of gene expression →	+0.072	+0.898	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,594 associations by consensus.

Heterochromatin organization by CNOT6 expression — STOMACH

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