Across TCGA pan-cancer cohorts, CNOT4P1 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of CNOT4P1’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CNOT4P1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CNOT4P1 is over-expressed in tumor.
HNSC and KIRC are the cancer types where CNOT4P1 tumor–normal differential expression is most reproducible.