CNOT3

Across TCGA patient cohorts, CNOT3 mutation is significantly associated with the total protein of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNOT3-associated genes across cancer lineages are eEF2, Cyclin-B1, and GAPDH. Each is linked with CNOT3 in more than 2 cancer types. Because this analysis shows association rather than direction, both CNOT3-to-partner and partner-to-CNOT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by CNOT3-low versus CNOT3-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNOT3→partner) and Y-score (partner→CNOT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	eEF2 →	+0.455	+3.000	.003	.036	3	3
UCEC	Cyclin-B1 →	+0.544	+1.700	.001	.001	3	3
UCEC	GAPDH →	+0.376	+1.584	.022	.032	3	3
UCEC	MEK1 →	+0.358	+2.137	.001	<.001	3	3
UCEC	MSH2 →	-0.237	-1.674	<.001	.040	3	3
UCEC	PKC-delta_pS664 →	-0.076	-1.415	.037	.040	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

eEF2 by CNOT3 expression — STAD

Explore this box plot interactively →