CNOT3

Across TCGA cell cohorts, CNOT3 mutation is significantly associated with the RNA expression of many other genes, with 722 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CNOT3-associated genes across cancer lineages are PABPC1L2B, TTC19, and PAIP2B. Each is linked with CNOT3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CNOT3-to-partner and partner-to-CNOT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PABPC1L2B grouped by CNOT3-low versus CNOT3-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNOT3→partner) and Y-score (partner→CNOT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	PABPC1L2B →	+0.099	+4.736	.009	.009	3	2
LARGE_INTESTINE	TTC19 →	+0.697	+2.502	<.001	.005	3	2
LARGE_INTESTINE	PAIP2B →	+0.823	+3.237	<.001	.003	3	2
LARGE_INTESTINE	SCLT1 →	+0.528	+2.502	.002	.005	3	2
BLOOD_Leukemia	CACNB2 →	+0.646	+3.259	.001	.006	3	2
LARGE_INTESTINE	ELP5 →	+0.802	+3.628	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 722 associations by consensus.

PABPC1L2B by CNOT3 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →