CNOT2

Across TCGA patient cohorts, CNOT2 protein abundance is significantly associated with the RNA expression of many other genes, with 6,536 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CNOT2-associated genes across cancer lineages are CCT2, PRMT1, and ENPP4. Each is linked with CNOT2 in more than 5 cancer types. Because this analysis shows association rather than direction, both CNOT2-to-partner and partner-to-CNOT2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CNOT2 versus CCT2 in HNSC, with a Pearson correlation of 0.23.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNOT2→partner) and Y-score (partner→CNOT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CCT2 →	+0.705	+0.167	.001	<.001	2	6
GBM	PRMT1 →	+0.492	+0.198	<.001	.002	3	4
GBM	ENPP4 →	-2.090	-0.264	<.001	<.001	3	4
HNSC	SPN →	-0.569	-0.140	.002	<.001	3	4
GBM	LILRA1 →	-0.523	-0.230	<.001	.004	3	3
HNSC	MS4A4E →	-0.505	-0.127	.009	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,536 associations by consensus.

CNOT2 vs CCT2 — HNSC

Explore this scatter interactively →