CNOT2

Across TCGA patient cohorts, CNOT2 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNOT2-associated genes across cancer lineages are Rab25, ATM, and Chk2_pT68. Each is linked with CNOT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CNOT2-to-partner and partner-to-CNOT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rab25 grouped by CNOT2-low versus CNOT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNOT2→partner) and Y-score (partner→CNOT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rab25 →	-0.352	-2.222	.005	.010	3	2
UCEC	ATM →	-0.641	-2.087	<.001	.005	3	2
UCEC	Chk2_pT68 →	-0.145	-3.295	.042	.009	3	2
UCEC	14-3-3_beta →	-0.108	-3.558	.005	.002	3	1
UCEC	eIF4E →	+0.159	+3.013	.049	.018	3	1
UCEC	ERK2 →	+0.186	+2.459	.012	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Rab25 by CNOT2 expression — UCEC

Explore this box plot interactively →