CNOT11

Across TCGA pan-cancer cohorts, CNOT11 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated CNOT11 data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher CNOT11 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CNOT11 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

UCEC, LUAD, and HNSC are the cancer types where CNOT11 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.949	0.769	.005	28	view →
LUAD	DFS	Quartile	III,IV	0.953	0.338	.006	7	view →
HNSC	DFS	Median	III,IV	0.698	0.864	.011	4	view →
CCRCC	OS	Tertile	All	0.772	1.000	.015	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

CNOT11–UCEC (DFS)

Open the UCEC breakdown →