CNOT11

Across TCGA patient cohorts, CNOT11 protein abundance is significantly associated with the RNA expression of many other genes, with 11,005 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CNOT11-associated genes across cancer lineages are HPGDS, ATP8B4, and SEPTIN4. Each is linked with CNOT11 in more than 6 cancer types. Because this analysis shows association rather than direction, both CNOT11-to-partner and partner-to-CNOT11 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CNOT11 versus HPGDS in LUAD, with a Pearson correlation of -0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNOT11→partner) and Y-score (partner→CNOT11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	HPGDS →	-0.986	-0.170	<.001	<.001	3	7
OV	ATP8B4 →	-0.840	-0.214	<.001	.004	3	6
GBM	SEPTIN4 →	-0.720	-0.154	<.001	<.001	3	6
OV	EFEMP1 →	-2.157	-0.229	<.001	<.001	3	6
OV	PDE1B →	-0.943	-0.269	<.001	<.001	3	6
OV	PTGER2 →	-0.873	-0.168	.004	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,005 associations by consensus.

CNOT11 vs HPGDS — LUAD

Explore this scatter interactively →