CNOT11

Across TCGA patient cohorts, CNOT11 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNOT11-associated genes across cancer lineages are FASN, ASNS, and 4E-BP1. Each is linked with CNOT11 in more than 1 cancer types. Because this analysis shows association rather than direction, both CNOT11-to-partner and partner-to-CNOT11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by CNOT11-low versus CNOT11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNOT11→partner) and Y-score (partner→CNOT11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.403	+1.765	.006	.014	3	2
UCEC	ASNS →	+0.458	+1.700	<.001	.042	3	2
UCEC	4E-BP1 →	+0.429	+3.700	<.001	.001	3	2
UCEC	eEF2 →	+0.363	+2.459	.006	.018	3	1
UCEC	ERK2 →	+0.207	+1.765	.004	.014	3	1
UCEC	FOXO3a_pS318_S321 →	-0.112	-1.668	.016	.021	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

FASN by CNOT11 expression — UCEC

Explore this box plot interactively →