CNOT11

Across TCGA cell cohorts, CNOT11 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible CNOT11-associated genes across cancer lineages are GPHB5, C1orf185, and KRTAP22-2. Each is linked with CNOT11 in more than 1 cancer types. Because this analysis shows association rather than direction, both CNOT11-to-partner and partner-to-CNOT11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPHB5 grouped by CNOT11-low versus CNOT11-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNOT11→partner) and Y-score (partner→CNOT11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GPHB5 →	+0.070	+4.887	<.001	.009	3	2
LUNG_NSCLC_LUAD	C1orf185 →	+0.053	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	KRTAP22-2 →	+0.221	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	SPATA31D1 →	+0.006	+5.228	<.001	.005	3	1
BREAST	OR10W1 →	+0.010	+4.781	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	GHRH →	+0.051	+4.736	.009	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

GPHB5 by CNOT11 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →