CNOT10

Across TCGA pan-cancer cohorts, CNOT10 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CNOT10 data layer compared with 23 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher CNOT10 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated CNOT10 expression acts as an unfavorable survival marker, although some lineages such as UCEC and COAD show a favorable association.

UCEC, CCRCC, and COAD are the cancer types where CNOT10 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	1.000	0.908	.011	32	view →
CCRCC	DFS	Quartile	All	0.615	0.961	.001	11	view →
COAD	DFS	Quartile	All	1.000	0.921	.040	6	view →
GBM	OS	Tertile	All	0.619	0.421	.014	4	view →
LUAD	OS	Quartile	III,IV	1.000	0.224	.029	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CNOT10–UCEC (OS)

Open the UCEC breakdown →