CNOT10

Across TCGA patient cohorts, CNOT10 mutation is significantly associated with the RNA expression of many other genes, with 3,804 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNOT10-associated genes across cancer lineages are HMGN2P32, SCARNA21B, and RN7SL25P. Each is linked with CNOT10 in more than 1 cancer types. Because this analysis shows association rather than direction, both CNOT10-to-partner and partner-to-CNOT10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMGN2P32 grouped by CNOT10-low versus CNOT10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNOT10→partner) and Y-score (partner→CNOT10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HMGN2P32 →	+0.407	+2.020	<.001	.002	3	2
READ	SCARNA21B →	+0.476	+5.039	<.001	.008	3	2
READ	RN7SL25P →	+0.308	+5.925	<.001	.002	3	2
UCEC	RN7SL714P →	+0.069	+2.393	.005	.008	3	2
COAD	BPY2DP →	+0.166	+5.087	<.001	.002	3	2
SKCM	KRT19P1 →	+0.068	+4.711	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,804 associations by consensus.

HMGN2P32 by CNOT10 expression — UCEC

Explore this box plot interactively →