CNOT10

Across TCGA patient cohorts, CNOT10 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNOT10-associated genes across cancer lineages are ATM, C-Raf, and Cyclin-B1. Each is linked with CNOT10 in more than 1 cancer types. Because this analysis shows association rather than direction, both CNOT10-to-partner and partner-to-CNOT10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by CNOT10-low versus CNOT10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNOT10→partner) and Y-score (partner→CNOT10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.666	-3.308	<.001	.009	3	2
UCEC	C-Raf →	+0.164	+1.678	.002	.023	3	2
UCEC	Cyclin-B1 →	+0.817	+2.584	<.001	.001	3	2
UCEC	14-3-3_beta →	-0.082	-1.847	.034	.049	3	1
UCEC	eEF2 →	+0.361	+3.459	.008	.005	3	1
UCEC	EGFR_pY1068 →	-0.344	-2.584	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

ATM by CNOT10 expression — UCEC

Explore this box plot interactively →