CNOT10

Across TCGA cell cohorts, CNOT10 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,920 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CNOT10-associated GO terms across cancer lineages are Sister chromatid cohesion, Double-strand break repair, and Double-strand break repair via homologous recombination. Each is linked with CNOT10 in more than 16 cancer types. Because this analysis shows association rather than direction, both CNOT10-to-partner and partner-to-CNOT10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Sister chromatid cohesion grouped by CNOT10-low versus CNOT10-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CNOT10→partner) and Y-score (partner→CNOT10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Sister chromatid cohesion →	+0.088	+0.994	.001	<.001	3	17
BLOOD_Myeloma	Double-strand break repair →	+0.063	+0.806	<.001	<.001	3	17
BLOOD_Myeloma	Double-strand break repair via homologous recombination →	+0.069	+0.781	<.001	<.001	3	16
KIDNEY	Positive regulation of spindle checkpoint →	+0.133	+0.825	<.001	<.001	3	16
KIDNEY	Positive regulation of mitotic cell cycle spindle assembly checkpoint →	+0.133	+0.825	<.001	<.001	3	16
OVARY	Regulation of double-strand break repair →	+0.068	+0.655	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,920 associations by consensus.

Sister chromatid cohesion by CNOT10 expression — KIDNEY

Explore this box plot interactively →