CNOT10

Across TCGA cell cohorts, CNOT10 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CNOT10-associated genes across cancer lineages are USP14, ALDH6A1, and ATP5F1A. Each is linked with CNOT10 in more than 1 cancer types. Because this analysis shows association rather than direction, both CNOT10-to-partner and partner-to-CNOT10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP14 grouped by CNOT10-low versus CNOT10-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNOT10→partner) and Y-score (partner→CNOT10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	USP14 →	+0.805	+3.067	.001	.009	3	1
LARGE_INTESTINE	ALDH6A1 →	+1.186	+3.064	<.001	.009	3	1
LARGE_INTESTINE	ATP5F1A →	+0.912	+3.082	.001	.007	3	1
LARGE_INTESTINE	EN1 →	+1.164	+3.536	<.001	.003	3	1
LARGE_INTESTINE	KRTAP10-2 →	+0.040	+2.672	.001	.004	3	1
LARGE_INTESTINE	SIKE1 →	+0.600	+3.064	.009	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

USP14 by CNOT10 expression — LARGE_INTESTINE

Explore this box plot interactively →