CNOT10-AS1

Across TCGA pan-cancer cohorts, CNOT10-AS1 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated CNOT10-AS1 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher CNOT10-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CNOT10-AS1 expression acts as an unfavorable survival marker, although some lineages such as BLCA and OV show a favorable association.

ACC, UVM, and BLCA are the cancer types where CNOT10-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Tertile	All	0.517	0.840	<.001	72	view →
UVM	DFS	Tertile	II,III,IV	0.115	0.770	<.001	72	view →
BLCA	DFS	Median	IV	0.350	0.141	.003	41	view →
LUSC	OS	Tertile	IV	0.001	0.673	.014	36	view →
TGCT	OS	Tertile	III,IV	0.501	1.000	.014	18	view →
OV	OS	Median	All	0.872	0.811	.014	16	view →
KIRC	DFS	Median	All	0.516	0.675	.017	15	view →
READ	OS	Tertile	All	0.451	0.712	.025	12	view →
LIHC	DFS	Tertile	II,III,IV	0.684	0.391	.013	12	view →
GBM	OS	Tertile	All	0.273	0.444	.041	9	view →
COAD	DFS	Tertile	IV	0.335	0.527	.033	9	view →
SKCM	DFS	Tertile	IV	0.134	0.589	.031	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

CNOT10-AS1–ACC (OS)

Open the ACC breakdown →