CNNM3

Across TCGA pan-cancer cohorts, CNNM3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CNNM3 data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher CNNM3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated CNNM3 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

CCRCC, LSCC, and UCEC are the cancer types where CNNM3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	III,IV	0.962	0.645	.006	29	view →
LSCC	OS	Median	All	0.910	0.709	<.001	20	view →
UCEC	OS	Median	II,III,IV	1.000	0.565	.004	8	view →
GBM	OS	Quartile	All	0.715	0.338	.001	8	view →
HNSC	OS	Median	II,III,IV	0.922	0.798	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CNNM3–CCRCC (OS)

Open the CCRCC breakdown →