CNNM3

Across TCGA cell cohorts, CNNM3 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible CNNM3-associated genes across cancer lineages are TGM7, TAFA1, and TAS2R60. Each is linked with CNNM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CNNM3-to-partner and partner-to-CNNM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TGM7 grouped by CNNM3-low versus CNNM3-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNNM3→partner) and Y-score (partner→CNNM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TGM7 →	+0.003	+2.887	<.001	.009	3	2
LARGE_INTESTINE	TAFA1 →	+0.274	+3.688	<.001	.002	3	1
LARGE_INTESTINE	TAS2R60 →	+0.017	+3.347	.005	.005	3	1
BLOOD_Leukemia	MYF5 →	+0.013	+5.201	<.001	.006	3	1
BLOOD_Leukemia	MYOD1 →	+0.025	+4.922	<.001	.009	3	1
BLOOD_Leukemia	ADGRA1 →	+0.006	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

TGM7 by CNNM3 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →