CNNM2

Across TCGA pan-cancer cohorts, CNNM2 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated CNNM2 data layer compared with 19 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher CNNM2 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated CNNM2 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

CCRCC, LSCC, and LUAD are the cancer types where CNNM2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	All	1.000	0.308	.005	14	view →
LSCC	DFS	Tertile	All	0.976	0.305	.017	2	view →
LUAD	DFS	Median	All	0.435	1.000	.016	2	view →
GBM	DFS	Median	All	0.776	0.657	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

CNNM2–CCRCC (OS)

Open the CCRCC breakdown →