CNNM2

Across TCGA patient cohorts, CNNM2 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNNM2-associated genes across cancer lineages are Caspase-7-cleavedD198, eEF2, and eIF4E. Each is linked with CNNM2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CNNM2-to-partner and partner-to-CNNM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CNNM2-low versus CNNM2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNNM2→partner) and Y-score (partner→CNNM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.585	+1.604	.002	.010	3	3
UCEC	eEF2 →	+0.349	+1.906	.002	.015	3	2
UCEC	eIF4E →	+0.185	+3.087	.006	<.001	3	2
UCEC	ERK2 →	+0.232	+2.502	<.001	.001	3	2
UCEC	MSH2 →	-0.229	-2.295	.002	.005	3	2
UCEC	Notch1 →	+0.103	+1.598	.023	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Caspase-7-cleavedD198 by CNNM2 expression — UCEC

Explore this box plot interactively →