CNNM2

Across TCGA cell cohorts, CNNM2 mutation is significantly associated with the RNA expression of many other genes, with 850 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CNNM2-associated genes across cancer lineages are LILRA1, MMP27, and FSHR. Each is linked with CNNM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CNNM2-to-partner and partner-to-CNNM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LILRA1 grouped by CNNM2-low versus CNNM2-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNNM2→partner) and Y-score (partner→CNNM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	LILRA1 →	+0.006	+4.906	<.001	.006	3	1
OESOPHAGUS	MMP27 →	+0.006	+4.906	<.001	.006	3	1
OESOPHAGUS	FSHR →	+0.013	+4.906	<.001	.006	3	1
OESOPHAGUS	GAGE12H →	+0.053	+4.906	<.001	.006	3	1
OESOPHAGUS	CCDC195 →	+0.043	+4.906	<.001	.006	3	1
LARGE_INTESTINE	ANKRD54 →	+0.504	+2.588	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 850 associations by consensus.

LILRA1 by CNNM2 expression — OESOPHAGUS

Explore this box plot interactively →