CNN3

Across TCGA pan-cancer cohorts, CNN3 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated CNN3 data layer compared with 25 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher CNN3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CNN3 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

LSCC, PDAC, and LUAD are the cancer types where CNN3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.477	0.870	<.001	38	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	10	view →
LUAD	DFS	Quartile	All	0.996	0.869	.017	3	view →
CCRCC	DFS	Median	III,IV	0.821	1.000	.020	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

CNN3–LSCC (DFS)

Open the LSCC breakdown →