CNN3

Across TCGA patient cohorts, CNN3 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNN3-associated genes across cancer lineages are ASNS, GAPDH, and Ku80. Each is linked with CNN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CNN3-to-partner and partner-to-CNN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by CNN3-low versus CNN3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNN3→partner) and Y-score (partner→CNN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.613	+2.584	<.001	.011	3	2
UCEC	GAPDH →	+0.607	+3.459	.015	.005	3	1
UCEC	Ku80 →	+0.270	+1.887	.014	.031	3	1
UCEC	MSH2 →	-0.451	-3.295	<.001	.009	3	1
UCEC	N-Ras →	-0.173	-2.295	.001	.033	3	1
UCEC	14-3-3_epsilon →	-0.094	-3.159	.042	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

ASNS by CNN3 expression — UCEC

Explore this box plot interactively →