Across TCGA pan-cancer cohorts, CNN2P11 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of CNN2P11’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where CNN2P11 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CNN2P11 is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.
LUSC and KIRC are the cancer types where CNN2P11 tumor–normal differential expression is most reproducible.