CNN2

Across TCGA pan-cancer cohorts, CNN2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CNN2 data layer compared with 21 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher CNN2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CNN2 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

LSCC, CCRCC, and PDAC are the cancer types where CNN2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.625	0.915	.002	22	view →
CCRCC	DFS	Quartile	II,III,IV	0.140	0.887	.038	12	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	10	view →
GBM	DFS	Median	All	0.625	0.806	.006	9	view →
COAD	DFS	Median	III,IV	0.829	1.000	.027	6	view →
HNSC	DFS	Tertile	II,III,IV	0.865	0.706	.039	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CNN2–LSCC (DFS)

Open the LSCC breakdown →