CNN2

Across TCGA cell cohorts, CNN2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,796 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible CNN2-associated GO terms across cancer lineages are Regulation of cell-substrate junction assembly, Regulation of focal adhesion assembly, and Actin filament organization. Each is linked with CNN2 in more than 13 cancer types. Because this analysis shows association rather than direction, both CNN2-to-partner and partner-to-CNN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cell-substrate junction assembly grouped by CNN2-low versus CNN2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CNN2→partner) and Y-score (partner→CNN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of cell-substrate junction assembly →	+0.150	+1.512	<.001	<.001	3	14
BONE	Regulation of focal adhesion assembly →	+0.150	+1.512	<.001	<.001	3	14
BONE	Actin filament organization →	+0.134	+1.334	<.001	<.001	3	13
BONE	Integrin-mediated signaling pathway →	+0.231	+1.240	<.001	<.001	3	13
LUNG_SCLC	Regulation of biological process involved in symbiotic interaction →	+0.169	+2.995	<.001	<.001	3	12
BONE	Regulation of cell-substrate adhesion →	+0.103	+1.048	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,796 associations by consensus.

Regulation of cell-substrate junction assembly by CNN2 expression — BONE

Explore this box plot interactively →