CNN1

Across TCGA patient cohorts, CNN1 mutation is significantly associated with the RNA expression of many other genes, with 2,372 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNN1-associated genes across cancer lineages are COX15, SKA1, and DONSON. Each is linked with CNN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CNN1-to-partner and partner-to-CNN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COX15 grouped by CNN1-low versus CNN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNN1→partner) and Y-score (partner→CNN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	COX15 →	+0.480	+2.592	<.001	.006	3	3
UCEC	SKA1 →	+0.898	+3.180	<.001	<.001	3	3
UCEC	DONSON →	+0.651	+3.732	<.001	<.001	3	3
UCEC	CHAF1B →	+0.709	+2.823	<.001	.001	3	3
UCEC	ZBTB8A →	+0.532	+3.743	<.001	<.001	3	3
UCEC	MAD2L1 →	+0.798	+2.523	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,372 associations by consensus.

COX15 by CNN1 expression — UCEC

Explore this box plot interactively →