CNN1

Across TCGA patient cohorts, CNN1 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNN1-associated genes across cancer lineages are eIF4E, Ku80, and Rab11. Each is linked with CNN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CNN1-to-partner and partner-to-CNN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by CNN1-low versus CNN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNN1→partner) and Y-score (partner→CNN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.243	+3.169	.017	.019	2	2
UCEC	Ku80 →	+0.378	+2.472	<.001	.011	3	1
UCEC	Rab11 →	-0.158	-3.169	.024	.018	3	1
UCEC	Rad50 →	-0.262	-2.459	.025	.020	3	1
UCEC	Annexin-1 →	+0.750	+3.019	.003	.019	3	1
UCEC	Tuberin →	+0.424	+2.331	.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

eIF4E by CNN1 expression — UCEC

Explore this box plot interactively →