CNN1

Across TCGA cell cohorts, CNN1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,387 significant associations in total. BONE shows the largest number of these associations.

The most reproducible CNN1-associated GO terms across cancer lineages are Aorta smooth muscle tissue morphogenesis, Regulation of smooth muscle cell-matrix adhesion, and Collagen fibril organization. Each is linked with CNN1 in more than 9 cancer types. Because this analysis shows association rather than direction, both CNN1-to-partner and partner-to-CNN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Aorta smooth muscle tissue morphogenesis grouped by CNN1-low versus CNN1-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CNN1→partner) and Y-score (partner→CNN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Aorta smooth muscle tissue morphogenesis →	+0.880	+0.963	<.001	<.001	3	10
SKIN	Regulation of smooth muscle cell-matrix adhesion →	+0.661	+0.923	<.001	.003	3	9
BONE	Collagen fibril organization →	+0.393	+3.738	<.001	<.001	3	9
LIVER	Transforming growth factor beta receptor signaling pathway →	+0.087	+4.415	<.001	<.001	3	9
BONE	Dentinogenesis →	+1.631	+2.736	.003	.001	3	9
BONE	Endodermal cell differentiation →	+0.166	+2.859	.004	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,387 associations by consensus.

Aorta smooth muscle tissue morphogenesis by CNN1 expression — LUNG_NSCLC_LUAD

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