CNKSR2

Across TCGA patient cohorts, CNKSR2 mutation is significantly associated with the RNA expression of many other genes, with 3,351 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNKSR2-associated genes across cancer lineages are CENPU, OXA1L, and CCNB2. Each is linked with CNKSR2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CNKSR2-to-partner and partner-to-CNKSR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CENPU grouped by CNKSR2-low versus CNKSR2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNKSR2→partner) and Y-score (partner→CNKSR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CENPU →	+0.893	+3.459	<.001	.005	3	3
UCEC	OXA1L →	+0.287	+2.686	<.001	<.001	3	3
UCEC	CCNB2 →	+0.530	+1.887	<.001	<.001	3	3
UCEC	SPC24 →	+0.524	+1.887	<.001	<.001	3	3
UCEC	B3GNT8 →	-0.513	-1.530	.008	.003	3	3
UCEC	MARK4 →	+0.316	+1.431	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,351 associations by consensus.

CENPU by CNKSR2 expression — COAD

Explore this box plot interactively →