CNKSR2

Across TCGA patient cohorts, CNKSR2 mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNKSR2-associated genes across cancer lineages are 4E-BP1, ASNS, and Raptor. Each is linked with CNKSR2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CNKSR2-to-partner and partner-to-CNKSR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by CNKSR2-low versus CNKSR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNKSR2→partner) and Y-score (partner→CNKSR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.321	+2.662	<.001	<.001	3	3
COAD	ASNS →	+0.841	+3.000	<.001	.035	3	3
SKCM	Raptor →	+0.186	+2.321	.037	.035	3	3
LUSC	Bcl-2 →	-0.275	-3.169	.044	.017	3	2
LUSC	Bid →	+0.108	+2.584	.008	.010	3	2
LUSC	C-Raf_pS338 →	+0.089	+2.477	.025	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

4E-BP1 by CNKSR2 expression — UCEC

Explore this box plot interactively →