CNKSR2

Across TCGA cell cohorts, CNKSR2 mutation is significantly associated with the RNA expression of many other genes, with 432 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CNKSR2-associated genes across cancer lineages are GPR119, CDR1, and ADH1A. Each is linked with CNKSR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CNKSR2-to-partner and partner-to-CNKSR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR119 grouped by CNKSR2-low versus CNKSR2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNKSR2→partner) and Y-score (partner→CNKSR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GPR119 →	+0.023	+3.196	<.001	.007	3	2
SKIN	CDR1 →	+0.237	+4.242	<.001	.001	3	2
BLOOD_Lymphoma	ADH1A →	+0.057	+3.954	<.001	.005	3	2
LUNG_NSCLC_LUAD	OR1L3 →	+0.012	+3.150	<.001	.006	3	2
BLOOD_Lymphoma	MAGEB10 →	+0.092	+3.927	<.001	.004	3	2
BLOOD_Lymphoma	OR52E4 →	+0.027	+4.058	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 432 associations by consensus.

GPR119 by CNKSR2 expression — SKIN

Explore this box plot interactively →