CNIH3

Across TCGA patient cohorts, CNIH3 protein abundance is significantly associated with the RNA expression of many other genes, with 220 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CNIH3-associated genes across cancer lineages are DNAJC5, ZNF574, and KCNA1. Each is linked with CNIH3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CNIH3-to-partner and partner-to-CNIH3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CNIH3 versus DNAJC5 in LSCC, with a Pearson correlation of 0.77.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNIH3→partner) and Y-score (partner→CNIH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DNAJC5 →	+0.610	+0.348	<.001	.001	3	1
LSCC	ZNF574 →	+0.693	+0.423	.001	<.001	3	1
LSCC	KCNA1 →	+0.126	+0.446	.008	.009	3	1
LSCC	ANOS1 →	+1.887	+0.348	.004	.001	3	1
LSCC	RPN2 →	+0.663	+0.348	<.001	.001	3	1
LSCC	NECAB1 →	+0.616	+0.426	.002	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 220 associations by consensus.

CNIH3 vs DNAJC5 — LSCC

Explore this scatter interactively →