CNIH3

Across TCGA patient cohorts, CNIH3 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNIH3-associated genes across cancer lineages are MSH2, Notch1, and ATM. Each is linked with CNIH3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CNIH3-to-partner and partner-to-CNIH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by CNIH3-low versus CNIH3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNIH3→partner) and Y-score (partner→CNIH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.247	-2.973	.033	.035	3	1
UCEC	Notch1 →	+0.217	+3.459	.002	.005	2	1
UCEC	ATM →	-0.959	-2.321	<.001	.035	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

MSH2 by CNIH3 expression — UCEC

Explore this box plot interactively →