CNIH3

Across TCGA cell cohorts, CNIH3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,704 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible CNIH3-associated GO terms across cancer lineages are Positive regulation of cell-substrate junction organization, Pyrimidine-containing compound transmembrane transport, and Vesicle-mediated transport to the plasma membrane. Each is linked with CNIH3 in more than 9 cancer types. Because this analysis shows association rather than direction, both CNIH3-to-partner and partner-to-CNIH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of cell-substrate junction organization grouped by CNIH3-low versus CNIH3-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CNIH3→partner) and Y-score (partner→CNIH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Positive regulation of cell-substrate junction organization →	+0.120	+1.276	.003	.003	3	10
LIVER	Pyrimidine-containing compound transmembrane transport →	-0.321	-2.549	<.001	<.001	3	9
CNS	Vesicle-mediated transport to the plasma membrane →	+0.055	+1.934	<.001	<.001	3	9
LIVER	Actin filament depolymerization →	+0.196	+1.669	.002	.004	3	9
SOFT_TISSUE	Regulation of collagen metabolic process →	+0.200	+2.224	<.001	<.001	3	8
LUNG_NSCLC_LUSC	Regulation of L-leucine import across plasma membrane →	-0.226	-2.212	.004	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,704 associations by consensus.

Positive regulation of cell-substrate junction organization by CNIH3 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →