CNIH3

Across TCGA cell cohorts, CNIH3 mutation is significantly associated with the mutation status of many other genes, with 807 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CNIH3-associated genes across cancer lineages are AQP6, SEPHS1, and EXOC1. Each is linked with CNIH3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CNIH3-to-partner and partner-to-CNIH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AQP6 grouped by CNIH3-low versus CNIH3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNIH3→partner) and Y-score (partner→CNIH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AQP6 →	+4.329	+4.329	.001	.001	1	2
LARGE_INTESTINE	SEPHS1 →	+3.329	+3.799	.005	.005	1	2
LARGE_INTESTINE	EXOC1 →	+2.422	+4.050	.004	.004	1	2
LARGE_INTESTINE	G2E3 →	+3.159	+4.632	<.001	<.001	1	2
LARGE_INTESTINE	CHMP7 →	+3.007	+3.584	.008	.008	1	2
LARGE_INTESTINE	ZC3H12C →	+2.936	+4.471	.001	.001	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 807 associations by consensus.

AQP6 by CNIH3 expression — LARGE_INTESTINE

Explore this box plot interactively →