CNIH2

Across TCGA pan-cancer cohorts, CNIH2 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CNIH2 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CNIH2 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated CNIH2 expression acts as an unfavorable survival marker.

HNSC, KIRP, and COAD are the cancer types where CNIH2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.099	0.712	<.001	36	view →
KIRP	OS	Median	All	0.184	0.885	<.001	15	view →
COAD	OS	Median	All	0.228	0.803	<.001	12	view →
SKCM	DFS	Median	All	0.058	0.757	<.001	12	view →
LIHC	DFS	Median	All	0.034	0.554	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CNIH2–HNSC (DFS)

Open the HNSC breakdown →