CNIH2

Across TCGA patient cohorts, CNIH2 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNIH2-associated genes across cancer lineages are C-Raf_pS338, eIF4E, and A-Raf_pS299. Each is linked with CNIH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CNIH2-to-partner and partner-to-CNIH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf_pS338 grouped by CNIH2-low versus CNIH2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNIH2→partner) and Y-score (partner→CNIH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf_pS338 →	-0.126	-3.000	.007	.037	3	1
UCEC	eIF4E →	+0.250	+3.000	.040	.037	2	1
UCEC	A-Raf_pS299 →	-0.178	-3.000	.010	.037	2	1
UCEC	MSH2 →	-0.335	-3.000	.011	.037	2	1
UCEC	JNK2 →	+0.366	+3.000	.001	.037	1	1
UCEC	SF2 →	-0.137	-2.986	.030	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

C-Raf_pS338 by CNIH2 expression — UCEC

Explore this box plot interactively →