CNIH2

Across TCGA cell cohorts, CNIH2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,272 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CNIH2-associated GO terms across cancer lineages are Positive regulation of DNA repair, Protein-DNA complex organization, and Regulation of double-strand break repair via homologous recombination. Each is linked with CNIH2 in more than 13 cancer types. Because this analysis shows association rather than direction, both CNIH2-to-partner and partner-to-CNIH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA repair grouped by CNIH2-low versus CNIH2-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CNIH2→partner) and Y-score (partner→CNIH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Positive regulation of DNA repair →	+0.085	+1.823	.001	.002	3	14
BONE	Protein-DNA complex organization →	+0.090	+1.574	.004	.003	3	14
BONE	Regulation of double-strand break repair via homologous recombination →	+0.110	+1.702	.002	.003	3	13
STOMACH	Positive regulation of double-strand break repair via homologous recombination →	+0.113	+1.963	<.001	<.001	3	13
BONE	Regulation of DNA repair →	+0.086	+1.423	.001	.007	3	13
LUNG_SCLC	Mitotic cytokinesis →	+0.080	+1.456	.001	.005	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,272 associations by consensus.

Positive regulation of DNA repair by CNIH2 expression — STOMACH

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