Across TCGA pan-cancer cohorts, CNIH1 mass-spec protein differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of CNIH1’s most consistent transcriptional readouts.
The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where CNIH1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types CNIH1 is over-expressed in tumor.
OV are the cancer types where CNIH1 tumor–normal differential expression is most reproducible.