CNIH1

Across TCGA patient cohorts, CNIH1 mutation is significantly associated with the RNA expression of many other genes, with 1,391 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNIH1-associated genes across cancer lineages are MED13P1, RNU7-147P, and RNU6-755P. Each is linked with CNIH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CNIH1-to-partner and partner-to-CNIH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MED13P1 grouped by CNIH1-low versus CNIH1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNIH1→partner) and Y-score (partner→CNIH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MED13P1 →	+0.144	+7.816	<.001	.008	3	1
SKCM	RNU7-147P →	+0.347	+7.816	<.001	.008	3	1
BRCA	RNU6-755P →	+1.027	+7.731	<.001	.009	3	1
BRCA	RN7SKP221 →	+0.099	+8.471	<.001	.005	3	1
BRCA	TRDD1 →	+1.367	+9.057	<.001	.003	3	1
BRCA	MTATP6P30 →	+0.054	+7.731	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,391 associations by consensus.

MED13P1 by CNIH1 expression — SKCM

Explore this box plot interactively →