CNGB3

Across TCGA patient cohorts, CNGB3 mutation is significantly associated with the RNA expression of many other genes, with 5,109 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNGB3-associated genes across cancer lineages are RITA1, USP39, and LETM1. Each is linked with CNGB3 in more than 4 cancer types. Because this analysis shows association rather than direction, both CNGB3-to-partner and partner-to-CNGB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RITA1 grouped by CNGB3-low versus CNGB3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNGB3→partner) and Y-score (partner→CNGB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RITA1 →	+0.517	+2.386	<.001	<.001	3	5
UCEC	USP39 →	+0.328	+3.032	<.001	<.001	3	5
UCEC	LETM1 →	+0.525	+2.093	<.001	<.001	3	5
UCEC	GCN1 →	+0.404	+2.137	.001	.009	3	5
UCEC	RTCB →	+0.427	+3.224	<.001	<.001	3	5
COAD	ACO2 →	+0.396	+2.807	.006	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,109 associations by consensus.

RITA1 by CNGB3 expression — UCEC

Explore this box plot interactively →