CNGB3

Across TCGA patient cohorts, CNGB3 mutation is significantly associated with the total protein of many other genes, with 76 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CNGB3-associated genes across cancer lineages are Shc_pY317, Caspase-7-cleavedD198, and JNK_pT183_Y185. Each is linked with CNGB3 in more than 3 cancer types. Because this analysis shows association rather than direction, both CNGB3-to-partner and partner-to-CNGB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by CNGB3-low versus CNGB3-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CNGB3→partner) and Y-score (partner→CNGB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	Shc_pY317 →	-0.164	-3.151	.012	.017	3	4
COAD	Caspase-7-cleavedD198 →	+0.730	+2.824	.027	.034	3	4
UCEC	JNK_pT183_Y185 →	-0.176	-2.584	.001	.010	3	3
LUSC	Chk2_pT68 →	+0.149	+2.816	.001	.001	3	3
UCEC	Notch1 →	+0.129	+2.009	.005	.005	3	3
UCEC	PCNA →	+0.286	+2.263	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 76 associations by consensus.

Shc_pY317 by CNGB3 expression — LUSC

Explore this box plot interactively →